Profiling and inhibiting reversible palmitoylation
نویسندگان
چکیده
منابع مشابه
Reversible palmitoylation of signaling proteins.
Palmitoylation is unique among lipid modifications of proteins in that it is reversible and regulable. Recent advances in the study of palmitoylation include the following: the correlation of this modification with the localization of a signaling protein to specific membrane subdomains; the demonstration of a specific protein-protein interaction that is promoted by palmitoylation; and the ident...
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Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory modification. Palmitoylated proteins can now be profiled in complex biological systems by MS for direct annotatio...
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immediate response of eukaryotic cells to oxidative. PARP-1 and PARP-2 display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. Recent studies suggest a link between DNA damage-induced poly(ADP-ribosyl)ation and all tissues at varying levels, with the highest activity in mammalian testis, spleen and thymus. in particula...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2013
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2012.11.023